Title: Carotid atherosclerosis and cognitive function in midlife: The beaver dam offspring study
Authors: Zhong, Wenjun
Cruickshanks, Karen J.
Huang, Guan-Hua
Klein, Barbara E. K.
Klein, Ronald
Nieto, F. Javier
Pankow, James S.
Schubert, Carla R.
National Chiao Tung University
Keywords: Atherosclerosis;Cognitive function;Epidemiology
Issue Date: 1-Nov-2011
Abstract: Background: Atherosclerosis may be associated with cognitive function; however the studies are few, especially among midlife adults. Methods: Participants in the beaver dam offspring study who had cognitive test data and gradable carotid artery ultrasound scans were included (n = 2794, mean age: 49 years). Atherosclerosis was measured by carotid intima-media thickness (IMT) and the presence of plaque. Cognitive function was measured by the trail making test (TMT), grooved pegboard test (GPT) and mini-mental state examination (MMSE). Generalized cognitive function was defined by a summary score calculated from the TMT and GPT. Linear regression was used to evaluate the associations between carotid atherosclerosis and cognitive function tests. Results: Larger IMT was associated with lower GPT, MMSE and the summary score adjusting for multiple factors, the coefficients were: 13.8s (p < 0.0001), -0.6 (p = 0.007), and 0.47 (p = 0.01), respectively for 1 mm increase in IMT. Plaque scores were significantly associated with TMT-B, GPT, MMSE, and the summary score adjusting for age, sex and education. The associations remained statistically significant after further adjustments except for the association with TMT-B, which was attenuated and no longer significant. Conclusions: Our results show the significant associations between markers of carotid atherosclerosis and cognitive function in a cohort of persons aged 21-84 years. Longitudinal studies are needed to further examine these associations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.atherosclerosis.2011.07.013
ISSN: 0021-9150
DOI: 10.1016/j.atherosclerosis.2011.07.013
Volume: 219
Issue: 1
Begin Page: 330
End Page: 333
Appears in Collections:Articles