標題: Plant miRNAs found in human circulating system provide evidences of cross kingdom RNAi
作者: Liu, Yu-Chen
Chen, Wen Liang
Kung, Wei-Hsiang
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
生物資訊研究中心
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Center for Bioinformatics Research
關鍵字: Circulating miRNAs;Plant miRNAs;miR2910;Cross Kingdom RNAi
公開日期: 1-Jan-2017
摘要: Background: Emerging evidence indicates that plant miRNAs can present within human circulating system through dietary intake and regulate human gene expression. Hence we deduced that comestible plants miRNAs can be identified in the public available small RNA sequencing data sets. Results: In this study, we identified abundant plant miRNAs sequences from 410 human plasma small RNA sequencing data sets. One particular plant miRNA miR2910, conserved in fruits and vegetables, was found to present in high relative amount in the plasma samples. This miRNA, with same 6mer and 7mer-A1 target seed sequences as hsa-miR-4259 and hsa-miR-4715-5p, was predicted to target human JAK-STAT signaling pathway gene SPRY4 and transcription regulation genes. Conclusions: Through analysis of public available plasma small RNA sequencing data, we found the supporting evidence for the plant miRNAs cross kingdom RNAi within human circulating system.
URI: http://dx.doi.org/10.1186/s12864-017-3502-3
http://hdl.handle.net/11536/146053
ISSN: 1471-2164
DOI: 10.1186/s12864-017-3502-3
期刊: BMC GENOMICS
Volume: 18
起始頁: 0
結束頁: 0
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