標題: Functional Connectivity of the Corpus Callosum in Epilepsy Patients with Secondarily Generalized Seizures
作者: Peng, Syu-Jyun
Hsin, Yue-Loong
電子工程學系及電子研究所
生醫電子轉譯研究中心
Department of Electronics Engineering and Institute of Electronics
Biomedical Electronics Translational Research Center
關鍵字: corpus callosum;resting-state function MRI;functional networks;regional homogeneity;secondarily generalized seizures
公開日期: 30-Aug-2017
摘要: The corpus callosum (CC) plays an important role in generalization of seizure activity. We used resting-state function magnetic resonance imaging (rs-fMRI) to investigate the regional and interregional functional connectivity of CC in patients with magnetic resonance imaging (MRI)-negative and secondarily generalized seizures. We measured the multi-regional coherences of blood oxygen level-dependent (BOLD) signals via rs-fMRI, cortical thickness via high-resolution T1-weighted MRI, and white matter (WM) integrity via diffusion-tensor imaging in 16 epilepsy patients as well as in 16 age-and gender-matched healthy subjects. All patients had non-lesional MRI, medically well-controlled focal epilepsy and history of secondarily generalized convulsions. Individuals with epilepsy had significant differences in regional and interregional hypersynchronization of BOLD signals intrahemispherically and interhemispherically, but no difference in cortical thickness and WM integrity. The only area with increased regional hypersynchrony in WM was over the anterior CC, which also exhibited lower activation of neighboring resting-state networks. The present study revealed abnormal local and distant synchronization of spontaneous neural activities in epileptic patients with secondarily generalized seizures.
URI: http://dx.doi.org/10.3389/fneur.2017.00446
http://hdl.handle.net/11536/146011
ISSN: 1664-2295
DOI: 10.3389/fneur.2017.00446
期刊: FRONTIERS IN NEUROLOGY
Volume: 8
起始頁: 0
結束頁: 0
Appears in Collections:Articles


Files in This Item:

  1. ba4f1bbc208302194040392f5018326c.pdf