標題: Increase the risk of intellectual disability in children with scabies: A nationwide population-based cohort study
作者: Liu, Jui-Ming
Hsu, Ren-Jun
Chang, Fung-Wei
Yeh, Chia-Lun
Huang, Chun-Fa
Chang, Shu-Ting
Chiu, Nan-Chang
Chang, Hung-Yang
Chi, Hsin
Lin, Chien-Yu
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: childhood psychiatric disorder;children;intellectual disability;mental disorder;mental health;National Health Insurance Research Database;scabies
公開日期: 1-Jun-2017
摘要: Scabies is a common and distressing disease caused by the mite Sarcoptes scabiei var. hominis. Psychiatric disorder in childhood is an important disease and easily neglected. There are several similarities in scabies and psychiatric disorders in childhood (PDC). Both of them may present with pruritus. They are relatively common in patients with lower socioeconomic status and crowded environment. Furthermore, immune-mediated inflammatory processes play a role in the pathophysiology in both diseases. An association between scabies and psychiatric disorders may exist. This nationwide population-based cohort study utilized data from the National Health Insurance Research Database to investigate the relationship between scabies and PDC. A total of 2137 children with scabies were identified as the study group and 8548 age- and sex-matched children were selected as the control group. A total of 607 (5.68%) children developed PDC during the 7-year follow-up period. The overall incidences of PDC are similar but patients with scabies had a higher risk of developing intellectual disability (ID) (scabies group vs control group: 1.3% vs 0.6%, adjusted hazard ratio: 2.04 and 95% confidence interval: 1.25-3.32). The immune-mediated inflammatory processes of both diseases were reviewed and may contribute to the 104% increased risk of interleukin in patients with scabies. We suggest a more comprehensive management in treating patients with scabies or ID. Early and comprehensive treatment of scabies and other risk factors may decrease the risk of subsequent ID. When we approach patients with ID, concurrent evaluation of scabies and other risk factors may contribute to successful management.
URI: http://dx.doi.org/10.1097/MD.0000000000007108
http://hdl.handle.net/11536/145616
ISSN: 0025-7974
DOI: 10.1097/MD.0000000000007108
期刊: MEDICINE
Volume: 96
Issue: 23
起始頁: 0
結束頁: 0
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