標題: Altered structural and functional thalamocortical networks in secondarily generalized extratemporal lobe seizures
作者: Peng, Syu-Jyun
Hsin, Yue-Loong
生醫電子轉譯研究中心
Biomedical Electronics Translational Research Center
關鍵字: Thalamocortical network;Generalized seizure;Gray matter density;Fractional anisotropy
公開日期: 1-Jan-2017
摘要: Structural and functional abnormalities in the thalamocortical network in primary generalized epilepsies or mesial temporal lobe epilepsy have recently been identified by voxel-wise analyses of neuroimaging. However, evidence is needed regarding the profiles of the thalamocortical network in patients with secondarily generalized seizures from focal neocortical sources. We used high-resolution T1-weighted, diffusion-tensor and resting-state functional MR imaging (rs-fMRI) to examine 16 patients with secondarily generalized extratemporal lobe seizures and 16 healthy controls. All the patients were medically effective and MRI-negative. Using whole brain voxel-based morphometry (VBM) to compare the patients with the normal controls, we observed significantly decreased gray matter (GM) density in the thalamus and 3 frontal gyri and significantly reduced white matter (WM) fractional anisotropy (FA) in the bilateral anterior corona radiata of the patients. Alterations in the thalamocortical functional connectivity with different cortices were identified by the rs-fMRI analysis seeding of the whole thalamus. The prefrontal gyri with the greatest functional connectivity were also traced by seeding a sub-thalamic region that is demarcated in an atlas, in which the thalamic parcellation is based on the WM connectivity to the cortices. This sub-thalamic region anatomically contains the mediodorsal thalamic nucleus where, concordantly, there was a significant decrease in thalamic GM density in the VBM study. In contrast to the negative correlation between the disease duration and reduced thalamic densities and subcortical FA values, the strength of the functional thalamocortical connectivity had a paradoxical correlation. Our results conclusively indicate that generalized seizures with a focal cortical source are associated with structural and functional alterations in the thalamocortical network. (C) 2016 The Authors. Published by Elsevier Inc.
URI: http://dx.doi.org/10.1016/j.nicl.2016.11.010
http://hdl.handle.net/11536/145519
ISSN: 2213-1582
DOI: 10.1016/j.nicl.2016.11.010
期刊: NEUROIMAGE-CLINICAL
Volume: 13
起始頁: 55
結束頁: 61
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