Full metadata record
DC FieldValueLanguage
dc.contributor.authorYan, Yung-Jheen_US
dc.contributor.authorHuang, Ting-Weien_US
dc.contributor.authorCheng, Nai-Lunen_US
dc.contributor.authorHsieh, Yao-Fangen_US
dc.contributor.authorTsai, Ming-Hsuien_US
dc.contributor.authorChiou, Jin-Chernen_US
dc.contributor.authorDuann, Jeng-Renen_US
dc.contributor.authorLin, Yung-Jiunen_US
dc.contributor.authorYang, Chin-Siangen_US
dc.contributor.authorMang Ou-Yangen_US
dc.date.accessioned2019-04-03T06:44:34Z-
dc.date.available2019-04-03T06:44:34Z-
dc.date.issued2017-04-01en_US
dc.identifier.issn1083-3668en_US
dc.identifier.urihttp://dx.doi.org/10.1117/1.JBO.22.4.045007en_US
dc.identifier.urihttp://hdl.handle.net/11536/145479-
dc.description.abstractOral cancer is a serious and growing problem in many developing and developed countries. To improve the cancer screening procedure, we developed a portable light-emitting-diode (LED)-induced autofluorescence (LIAF) imager that contains two wavelength LED excitation light sources and multiple filters to capture ex vivo oral tissue autofluorescence images. Compared with conventional means of oral cancer diagnosis, the LIAF imager is a handier, faster, and more highly reliable solution. The compact design with a tiny probe allows clinicians to easily observe autofluorescence images of hidden areas located in concave deep oral cavities. The ex vivo trials conducted in Taiwan present the design and prototype of the portable LIAF imager used for analyzing 31 patients with 221 measurement points. Using the normalized factor of normal tissues under the excitation source with 365 nm of the central wavelength and without the bandpass filter, the results revealed that the sensitivity was larger than 84%, the specificity was not smaller than over 76%, the accuracy was about 80%, and the area under curve of the receiver operating characteristic (ROC) was achieved at about 87%, respectively. The fact shows the LIAF spectroscopy has the possibilities of ex vivo diagnosis and noninvasive examinations for oral cancer. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)en_US
dc.language.isoen_USen_US
dc.subjectautofluorescenceen_US
dc.subjectoral canceren_US
dc.subjectmultispectrumen_US
dc.subjectLEDen_US
dc.subjectmedical and biological imagingen_US
dc.subjectoptical diagnosisen_US
dc.subjecttissue diagnostics statics for medicineen_US
dc.titlePortable LED-induced autofluorescence spectroscopy for oral cancer diagnosisen_US
dc.typeArticleen_US
dc.identifier.doi10.1117/1.JBO.22.4.045007en_US
dc.identifier.journalJOURNAL OF BIOMEDICAL OPTICSen_US
dc.citation.volume22en_US
dc.citation.issue4en_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department分子醫學與生物工程研究所zh_TW
dc.contributor.department電機工程學系zh_TW
dc.contributor.department電控工程研究所zh_TW
dc.contributor.departmentInstitute of Molecular Medicine and Bioengineeringen_US
dc.contributor.departmentDepartment of Electrical and Computer Engineeringen_US
dc.contributor.departmentInstitute of Electrical and Control Engineeringen_US
dc.identifier.wosnumberWOS:000400896100028en_US
dc.citation.woscount1en_US
Appears in Collections:Articles


Files in This Item:

  1. 6fc8613a7598063adca930364d0e924e.pdf