標題: Portable LED-induced autofluorescence spectroscopy for oral cancer diagnosis
作者: Yan, Yung-Jhe
Huang, Ting-Wei
Cheng, Nai-Lun
Hsieh, Yao-Fang
Tsai, Ming-Hsui
Chiou, Jin-Chern
Duann, Jeng-Ren
Lin, Yung-Jiun
Yang, Chin-Siang
Mang Ou-Yang
分子醫學與生物工程研究所
電機工程學系
電控工程研究所
Institute of Molecular Medicine and Bioengineering
Department of Electrical and Computer Engineering
Institute of Electrical and Control Engineering
關鍵字: autofluorescence;oral cancer;multispectrum;LED;medical and biological imaging;optical diagnosis;tissue diagnostics statics for medicine
公開日期: 1-Apr-2017
摘要: Oral cancer is a serious and growing problem in many developing and developed countries. To improve the cancer screening procedure, we developed a portable light-emitting-diode (LED)-induced autofluorescence (LIAF) imager that contains two wavelength LED excitation light sources and multiple filters to capture ex vivo oral tissue autofluorescence images. Compared with conventional means of oral cancer diagnosis, the LIAF imager is a handier, faster, and more highly reliable solution. The compact design with a tiny probe allows clinicians to easily observe autofluorescence images of hidden areas located in concave deep oral cavities. The ex vivo trials conducted in Taiwan present the design and prototype of the portable LIAF imager used for analyzing 31 patients with 221 measurement points. Using the normalized factor of normal tissues under the excitation source with 365 nm of the central wavelength and without the bandpass filter, the results revealed that the sensitivity was larger than 84%, the specificity was not smaller than over 76%, the accuracy was about 80%, and the area under curve of the receiver operating characteristic (ROC) was achieved at about 87%, respectively. The fact shows the LIAF spectroscopy has the possibilities of ex vivo diagnosis and noninvasive examinations for oral cancer. (C) 2017 Society of Photo-Optical Instrumentation Engineers (SPIE)
URI: http://dx.doi.org/10.1117/1.JBO.22.4.045007
http://hdl.handle.net/11536/145479
ISSN: 1083-3668
DOI: 10.1117/1.JBO.22.4.045007
期刊: JOURNAL OF BIOMEDICAL OPTICS
Volume: 22
Issue: 4
起始頁: 0
結束頁: 0
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