標題: Reverse thermo-responsive hydrogels prepared from Pluronic F127 and gelatin composite materials
作者: Yeh, Mei-Yu
Zhao, Jiong-Yao
Hsieh, Yi-Ru
Lin, Jhong-Hua
Chen, Fang-Yi
Chakravarthy, Rajan Deepan
Chung, Pei-Chun
Lin, Hsin-Chieh
Hung, Shih-Chieh
材料科學與工程學系
Department of Materials Science and Engineering
公開日期: 1-Jan-2017
摘要: Gelatin is an important hydrocolloid which has widespread applications in the pharmaceutical industry and biomedical science. However, despite its significance, clinical applications of gelatin are largely limited because of its gel-to-solution transition around human body temperature. In this work, we developed a series of F127-gelatin composite hydrogels with reverse thermo-responsive properties. The stiffness of F127-gelatin hydrogels can be adjusted by varying the types and contents of gelatin (type A, GA and type B, GB). The results of rheological data showed that F127-GA gels have higher gel strengths than those of F127-GB, which might be due to different isoelectric points between GA and GB. In addition, F127-gelatin gels showed significant cell viability and biocompatibility for human mesenchymal stem cells, indicating that these discovered hydrogels can serve as potential biomaterials and implantable scaffolds for applications in tissue engineering and regenerative medicine.
URI: http://dx.doi.org/10.1039/c7ra01118k
http://hdl.handle.net/11536/145403
ISSN: 2046-2069
DOI: 10.1039/c7ra01118k
期刊: RSC ADVANCES
Volume: 7
Issue: 34
起始頁: 21252
結束頁: 21257
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