標題: Photodynamic dye adsorption and release performance of natural zeolite
作者: Hovhannisyan, Vladimir
Dong, Chen-Yuan
Chen, Shean-Jen
光電學院
College of Photonics
公開日期: 31-Mar-2017
摘要: Clinoptilolite type of zeolite (CZ) is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms and organic molecules into micropores. Using multiphoton microscopy, we demonstrated that individual CZ particles produce two-photon excited luminescence and second harmonic generation signal at femtosecond laser excitation, and adsorb photo-dynamically active dyes such as hypericin and methylene blue. Furthermore, the release of hypericin from CZ pores in the presence of biomolecules is shown, and CZ can be considered as an effective material for drug delivery and controlled release in biological systems. The results may open new perspectives in application of CZ in biomedical imaging, and introducing of the optical approaches into the clinical environment.
URI: http://dx.doi.org/10.1038/srep45503
http://hdl.handle.net/11536/145293
ISSN: 2045-2322
DOI: 10.1038/srep45503
期刊: SCIENTIFIC REPORTS
Volume: 7
起始頁: 0
結束頁: 0
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