標題: Cucumarioside A(2)-2 Causes Macrophage Activation in Mouse Spleen
作者: Pislyagin, Evgeny A.
Manzhulo, Igor V.
Gorpenchenko, Tatiana Y.
Dmitrenok, Pavel S.
Avilov, Sergey A.
Silchenko, Alexandra S.
Wang, Yun-Ming
Aminin, Dmitry L.
生物科技學系
Department of Biological Science and Technology
關鍵字: immunomodulation;LPS;iba-1;IL-1;NO;iNOs;ROS;sea cucumbers;spleen;triterpene glycosides
公開日期: 1-Nov-2017
摘要: The immunomodulatory effect of triterpene glycoside cucumarioside A(2)-2 (CA(2)-2), isolated from the Far Eastern sea cucumber Cucumaria japonica, was compared with lipopolysaccharide (LPS) on mouse spleen. It has been shown that the intraperitoneal (i.p.) glycoside administration leads to increased spleen macrophage activating markers iba-1, IL-1, iNOs, ROS and NO formation, with additional change of macrophage phenotype to M1. The mass spectrometry profiles of peptide/protein were obtained using MALDI-TOF-MS on the different parts of spleen sections isolated by laser mircodissection techniques. It was found that i.p. stimulation of animals with CA(2)-2 leads to marked changes in the intensity of the characteristic peaks of spleen peptides/proteins, primarily in red pulp.
URI: http://dx.doi.org/10.3390/md15110341
http://hdl.handle.net/11536/144150
ISSN: 1660-3397
DOI: 10.3390/md15110341
期刊: MARINE DRUGS
Volume: 15
Issue: 11
起始頁: 0
結束頁: 0
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