標題: Bacterial alterations in salivary microbiota and their association in oral cancer
作者: Lee, Wei-Hsiang
Chen, Hui-Mei
Yang, Shun-Fa
Liang, Chao
Peng, Chih-Yu
Lin, Feng-Mao
Tsai, Lo-Lin
Wu, Buor-Chang
Hsin, Chung-Han
Chuang, Chun-Yi
Yang, Ting
Yang, Tzu-Ling
Ho, Shinn-Ying
Chen, Wen-Liang
Ueng, Kwo-Chang
Huang, Hsien-Da
Huang, Chien-Ning
Jong, Yuh-Jyh
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 28-Nov-2017
摘要: Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity and the fourth leading malignancy and cause of cancer-related death in the male population of Taiwan. Most cases are detected at advanced stages, resulting in poor prognosis. Therefore, improved detection of early oral health disorders is indispensable. The involvement of oral bacteria in inflammation and their association with OSCC progression provide a feasible target for diagnosis. Due to the nature of oral neoplasms, the diagnosis of epithelial precursor lesions is relatively easy compared with that of other types of cancer. However, the transition from an epithelial precursor lesion to cancer is slow and requires further and continuous follow-up. In this study, we investigated microbiota differences between normal individuals, epithelial precursor lesion patients, and cancer patients with different lifestyle habits, such as betel chewing and smoking, using next-generation sequencing. Overall, the oral microbiome compositions of five genera, Bacillus, Enterococcus, Parvimonas, Peptostreptococcus, and Slackia, revealed significant differences between epithelial precursor lesion and cancer patients and correlated with their classification into two clusters. These composition changes might have the potential to constitute a biomarker to help in monitoring the oral carcinogenesis transition from epithelial precursor lesion to cancer.
URI: http://dx.doi.org/10.1038/s41598-017-16418-x
http://hdl.handle.net/11536/144137
ISSN: 2045-2322
DOI: 10.1038/s41598-017-16418-x
期刊: SCIENTIFIC REPORTS
Volume: 7
起始頁: 0
結束頁: 0
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