標題: Epidemiology and antifungal susceptibility of candidemia isolates of non-albicans Candida species from cancer patients
作者: Wu, Ping-Feng
Liu, Wei-Lun
Hsieh, Min-Han
Hii, Ing-Moi
Lee, Yu-Lin
Lin, Yi-Tsung
Ho, Mao-Wang
Liu, Chun-Eng
Chen, Yen-Hsu
Wang, Fu-Der
生物科技學系
Department of Biological Science and Technology
關鍵字: cancer;epidemiology;non-albicans candidemia;susceptibility
公開日期: 11-Oct-2017
摘要: Candidemia is a growing concern worldwide, and its species distribution has shifted toward non-albicans Candida in recent decades, especially in patients with malignancy. This study aimed to update the epidemiology and antifungal susceptibility of non-albicans candidemia isolates from the cancer patients. Adult cancer patients with non-albicans candidemia were recruited, and clinical data were retrospectively collected from five medical centers in Taiwan from 1 July 2011 to 30 June 2014. In vitro susceptibility was determined by the broth dilution method using a Sensititre YeastOne system and interpreted according to the guidelines of the Clinical and Laboratory Standards Institute. A total of 346 episodes of non-albicans candidemia were identified in cancer patients. Candida tropicalis was the most common species (n=145, 41.9%) and had the highest resistance rate to fluconazole (n=17, 13.9%) among all the preserved isolates, including C. tropicalis, Candida glabrata and Candida parapsilosis. A higher Charlson comorbidity index, non-albicans candidemia due to C. tropicalis, neutropenia and septic shock were independent predictors of 28-day mortality. In conclusion, the species distribution and antifungal susceptibility of non-albicans candidemia isolates in our study differed from those in Western countries, providing useful information about local epidemiology for the selection of empirical antifungal agents for cancer patients.
URI: http://dx.doi.org/10.1038/emi.2017.74
http://hdl.handle.net/11536/143963
ISSN: 2222-1751
DOI: 10.1038/emi.2017.74
期刊: EMERGING MICROBES & INFECTIONS
Volume: 6
起始頁: 0
結束頁: 0
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