Health effects of particles, ions and residual aluminium in drinking water on mice during high-fat feeding
|關鍵字:||顆粒及離子;殘餘鋁;小鼠試驗;飲用水;高油飲食;氧化壓力;發炎反應;particles and ions;residual aluminium;drinking water;mice;high-fat feeding;oxidative stress;inflammation|
另外暴露不同鋁濃度後得到可觀察不良影響的最低值(LOAEL)為5 mg/L (0.914 mg/kg)，而參考劑量(RfD)為0.0091 mg/kg-day，在此濃度下便會對小鼠腎臟、脾臟及肝臟產生影響，若將鋁濃度提高至25 mg/L，則會對大腦、腎臟、脾臟、肝臟及睪丸五種目標器官皆產生健康影響。|
Particless, ions and residual aluminum (Al) after water purification processes have raised numerous concerns for the safety of drinking water. Considering dietary habits, the long-term consumption of high-fat foods also possibly causes the negative effects on human health. Our current survey reveals that the utilization of drinking water containing high amount of residual Al accompanying by high-fat dietary habit may simultaneously result in the inflammation effect on some organs in human body. This study aimed to assess the effects of the long-term coupling utilization of drinking water containing particles, ions and different dietary habits (normal and high-fat feeding) on the health of mice. Particularly, our study included two parts. The first part investigated the co-effects of different Al forms (particle and ionic) and different dietary habits on mice, and the second part investigated the effects of different Al concentration. Firstly, tap waters containing Al as feeding water were prepared via two filtration processes, ie, ultrafiltration (UF) and reverse osmosis (RO), which applied to feed the mice. The co-effects of three exposure tap water samples (1) un-treated tap water, (2) tap water after UF, and (3) tap water after RO and different dietary habits (normal and high-fat feeding) on the mice were investigated. Secondly, synthetic tap waters with different Al concentrations were also prepared to survey the various effects of Al on the health of mice. The result has found that the normal-fat feeding coupling with RO filtration water and high-fat feeding with un-treated tap water had negatively greatest impact on the health of mice. Specifically, oxidative stress and inflammation have significantly been observed in the brain, kidney, spleen, liver and testis of tested mice (p<0.05). The negative effects of RO filtration water possibly results from the lack of essential elements, such as calcium, magnesium and potassium and other trace elements. After RO filtration, drinking water without any particles and ions existed. The long-term intake of such water possibly causes stresses on the mice body. In case of un-treated tap water, the stresses may cause by the co-effect of aluminum concentration in tap water and high-fat feeding. This study implies that drinking water after UF filtration has the smallest affects on the health of mice even under high-fat dietary habit. The results of different Al concentration test reveals that the lowest-observed-adverse- effect level (LOAEL) of aluminium was 5 mg / L (0.914 mg/ kg), and the reference dose (RfD) was 0.0091 mg/kg/day. In such exposure dose of Al, kidneys, spleen and liver are mostly affected.
|Appears in Collections:||Thesis|