標題: Synthesis of alpha-galactosyl ceramide and the related glycolipids for evaluation of their activities on mouse splenocytes
作者: Fan, GT
Pan, YS
Lu, KC
Cheng, YP
Lin, WC
Lin, S
Lin, CH
Wong, CH
Fang, JM
Lin, CC
應用化學系
Department of Applied Chemistry
關鍵字: phytosphingosine;alpha-galactosyl ceramide;immuno stimulator;glycolipid
公開日期: 14-Feb-2005
摘要: Phytosphingosine and its short-chain analog were efficiently synthesized with 19% overall yield in 10 steps, respectively, starting from an inexpensive D-lyxose. Galactosyl donors of sulfide and phosphite types bearing benzoyl protecting groups of 4- and 6OH underwent glycosylation in excellent alpha-anomeric selectivity. A variety of alpha-galactosyl, fucosyl and glucosyl ceramides and serine-type lipids were prepared, and their activities involved in the proliferation of mouse splenocytes and the expression of cytokines were elucidated. Besides alpha-galactosyl ceramides, a galactosyl serine-type lipid also exhibited substantial effect on the expression of cytokines IFN-gamma and IL-4. (C) 2004 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tet.2004.12.027
http://hdl.handle.net/11536/14003
ISSN: 0040-4020
DOI: 10.1016/j.tet.2004.12.027
期刊: TETRAHEDRON
Volume: 61
Issue: 7
起始頁: 1855
結束頁: 1862
Appears in Collections:Articles


Files in This Item:

  1. 000226915200024.pdf