標題: Distribution and susceptibility to amphotericin B and fluconazole of Candida spp. isolated from Taiwan
作者: Yang, YL
Ho, YA
Cheng, HH
Lo, HJ
生物科技學系
Department of Biological Science and Technology
公開日期: 1-Apr-2005
摘要: Susceptibilities to amphotericin B and fluconazole of 628 clinical yeast strains collected from 22 hospitals in Taiwan were determined. A total of 53 isolates (8.4%) were resistant to fluconazole. Each hospital had different resistance rate to fluconazole ranging from 0 % to 24 %. None of the 186 isolates from eight of the 22 hospitals was resistant to fluconazole. In contrast, isolates from nine of the remaining 14 hospitals had greater than 10 % resistance rate to fluconazole. Consistently, 88.9 % (8/9) fluconazole-resistant C. albicans isolates were from hospitals having a high resistance rate to fluconazole. The prevalence of various Candida spp. in each hospital was different. A positive association was found between the prevalence of C. tropicalis and the resistance rate to fluconazole for individual hospitals. Although only three isolates (0.5 %) were resistant to amphotericin B, a co-resistance to both amphotericin B and fluconazole was observed, which highlights the emerging problem of drug resistance.
URI: http://dx.doi.org/10.1017/S0950268804003310
http://hdl.handle.net/11536/13875
ISSN: 0950-2688
DOI: 10.1017/S0950268804003310
期刊: EPIDEMIOLOGY AND INFECTION
Volume: 133
Issue: 2
起始頁: 325
結束頁: 330
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