標題: Microwave-assisted benzimidazole cyclization by bismuth chloride
作者: Su, YS
Sun, CM
應用化學系
Department of Applied Chemistry
關鍵字: bismuth chloride;combinatorial chemistry;liquid-phase method;microwave assisted synthesis;scaffold
公開日期: 17-五月-2005
摘要: We have developed a multi-step, microwave-assisted method for the bismuth chloride catalyzed synthesis of 1,2-disubstituted benzimidazoles. Biologically interesting benzimidazoles were readily assembled using a SNAr reaction, reduction, and finally a bismuth(III)-mediated cyclization under microwave irradiation. The desired products were then liberated from the soluble matrix in excellent yield and purity after cleavage. Each step of the synthetic sequence was performed under microwave conditions.
URI: http://dx.doi.org/10.1055/s-2005-865240
http://hdl.handle.net/11536/13706
ISSN: 0936-5214
DOI: 10.1055/s-2005-865240
期刊: SYNLETT
Volume: 
Issue: 8
起始頁: 1243
結束頁: 1246
顯示於類別:期刊論文


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  1. 000229298900006.pdf