標題: Polymorphism for transforming growth factor beta 1-509 (TGF-B1-509): Association with endometriosis
作者: Hsieh, YY
Chang, CC
Tsai, FJ
Peng, CT
Yeh, LS
Lin, CC
生物科技學系
Department of Biological Science and Technology
關鍵字: cytokine;endometriosis;polymorphism;transforming growth factor
公開日期: 1-六月-2005
摘要: Transforming growth factor beta (TGF-B) family members are multi-functional cytokines that play a key role in cellular growth, proliferation, and differentiation. The aim of the study was to investigate whether the TGF-B1-509 gene polymorphism could be used as a marker of susceptibility in endometriosis. Women were divided into two groups: endometriosis (n = 150) and non-endometriosis (n = 159). Polymorphisms for TGF-B1-509 genes were amplified by polymerase chain reaction and detected after restriction enzyme digestion. Genotypes and allelic frequencies in both groups were compared. Genotype proportions and allele frequencies of TGF-B1 gene polymorphisms differed significantly in both groups. Proportions of C homozygote, heterozygote, and T homozygote for TGF-B1 gene polymorphisms were 9.3/61.3/29.4% in the endometriosis group and 41.3/58.5/0% in the non-endometriosis group. Alleles C and T for TGF-B1 gene polymorphism were 40/60% (endometriosis) and 70.8/29.2% (non-endometriosis). Association of endometriosis with TGF-B1-509 gene polymorphism exists. T homozygote and T allele for TGF-B1 are associated with higher susceptibility to endometriosis.
URI: http://dx.doi.org/10.1007/s10528-005-5211-x
http://hdl.handle.net/11536/13621
ISSN: 0006-2928
DOI: 10.1007/s10528-005-5211-x
期刊: BIOCHEMICAL GENETICS
Volume: 43
Issue: 5-6
起始頁: 203
結束頁: 210
顯示於類別:期刊論文


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