Title: Effect of Peptide Sequences on Supramolecular Interactions of Naphthaleneimide/Tripeptide Conjugates
Authors: Yeh, Mei-Yu
Huang, Ching-Ting
Lai, Tsung-Sheng
Chen, Fang-Yi
Chu, Nien-Tzu
Tseng, Dion Tzu-Huan
Hung, Shih-Chieh
Lin, Hsin-Chieh
Department of Materials Science and Engineering
Issue Date: 2-Aug-2016
Abstract: In this study, we reported a significant difference in the supramolecular hydrogelation of newly discovered NI-GFF (NI-Gly-L-Phe-L-Phe) and NI-FFG (NI-L-Phe-L-Phe-Gly) on the basis of their phase diagrams. With a small difference in the peptide chain between NI-GFF and NI-FFG, we observed a significant difference in their self-assembly properties; NI-GFF formed a stable gel at neutral pH, whereas NI-FFG did not, under the same conditions. From spectroscopic and computational studies, intermolecular pi-pi interactions and extended hydrogen bonding interactions might reinforce the intermolecular interactions of NI-GFF, which may facilitate the formation of the self-assembled nanostructures and the hydrogel. In addition, the aggregation-induced emission (AIE)-active NI-GFF reveals relatively good biocompatibility compared with that of NI-FFG for two commonly used cell lines, suggesting that it is a promising candidate for use as a supramolecular material in biomedical applications. Our results highlight the importance of tripeptide sequences in a self-assembling hydrogel system.
URI: http://dx.doi.org/10.1021/acs.langmuir.6b01809
ISSN: 0743-7463
DOI: 10.1021/acs.langmuir.6b01809
Volume: 32
Issue: 30
Begin Page: 7630
End Page: 7638
Appears in Collections:Articles