Title: Selective C(8)-H Activation of Imidazopyridines Mediated by Cooperative Nickel-Aluminum Catalysis
Authors: Liu, Cheng-Yuan
Chen, Ying-Ho
Chen, Chih-Hao
Yu, Ming-Shiuan
Tsai, Fu-Yu
Ong, Tiow-Gan
Department of Applied Chemistry
Keywords: C-H activation;nickel;aluminum;imidazopyridines;cooperative catalysis
Issue Date: Sep-2016
Abstract: A catalytic paradigm is described featuring a synergistic interaction between nickel, aluminum and different ligands to impart a rather remote C-H alkenylation of imidazo[1,5-a] pyridines at the C-8 position without the necessity of installing a directing group. The scope of the direct C-H activation reactions of various 5-aryl- and 3-arylimidazopyridines is established using different sterically hindered alkynes.
URI: http://dx.doi.org/10.1055/s-0035-15661438
ISSN: 0039-7881
DOI: 10.1055/s-0035-15661438
Volume: 48
Issue: 17
Begin Page: 2781
End Page: 2788
Appears in Collections:Articles