標題: Serum Galectin-9 and Galectin-3-Binding Protein in Acute Dengue Virus Infection
作者: Liu, Kuan-Ting
Liu, Yao-Hua
Chen, Yen-Hsu
Lin, Chun-Yu
Huang, Chung-Hao
Yen, Meng-Chi
Kuo, Po-Lin
生物科技學系
Department of Biological Science and Technology
關鍵字: galectin;glycoprotein;serum;dengue;galectin-9;galectin-3 binding protein;adult;fever
公開日期: 1-Jun-2016
摘要: Dengue fever is a serious threat for public health and induces various inflammatory cytokines and mediators, including galectins and glycoproteins. Diverse immune responses and immunological pathways are induced in different phases of dengue fever progression. However, the status of serum galectins and glycoproteins is not fully determined. The aim of this study was to investigate the serum concentration and potential interaction of soluble galectin-1, galectin-3, galectin-9, galectin-3 binding protein (galectin-3BP), glycoprotein 130 (gp130), and E-, L-, and P-selectin in patients with dengue fever in acute febrile phase. In this study, 317 febrile patients (187 dengue patients, 150 non-dengue patients that included 48 patients with bacterial infection and 102 patients with other febrile illness) who presented to the emergency department and 20 healthy controls were enrolled. Our results showed the levels of galectin-9 and galectin-3BP were significantly higher in dengue patients than those in healthy controls. Lower serum levels of galectin-1, galectin-3, and E-, L-, and P-selectin in dengue patients were detected compared to bacteria-infected patients, but not to healthy controls. In addition, strong correlation between galectin-9 and galectin-3BP was observed in dengue patients. In summary, our study suggested galectin-9 and galectin-3BP might be critical inflammatory mediators in acute dengue virus infection.
URI: http://dx.doi.org/10.3390/ijms17060832
http://hdl.handle.net/11536/133949
ISSN: 1422-0067
DOI: 10.3390/ijms17060832
期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume: 17
Issue: 6
起始頁: 0
結束頁: 0
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