Title: The use of polymer-based nanoparticles and nanostructured materials in treatment and diagnosis of cardiovascular diseases: Recent advances and emerging designs
Authors: Wang, Yen-Jen
Larsson, Mikael
Huang, Wei-Ting
Chiou, Shih-Hwa
Nicholls, Stephen J.
Chao, Jui-I
Liu, Dean-Mo
Department of Materials Science and Engineering
Department of Biological Science and Technology
Keywords: Cardiovascular diseases;Drug delivery;Nanoparticles;Nanostructured;Polymers;Theranostic
Issue Date: Jun-2016
Abstract: This review summarizes important advances in polymer-based nanotechnologies for the treatment and diagnosis of cardiovascular diseases, focusing on nanoparticles and nanostructured materials/devices. The current state of the art and design parameters are discussed with the aim of providing a source of information that can aid in the development of new treatments by bridging between materials development, preclinical, and clinical trials. This is highly relevant as cardiovascular diseases remain a leading cause of death worldwide and as current treatments burden the healthcare systems with great costs. Different strategies, from targeting theranostic nanocarriers, to dual-drug depot systems, injectable cell scaffolds, and LDL acceptors are treated. The review ends with a concluding outlook on the ossibilities and challenges presented to polymer-based nanotechnologies in cardiovascular disease therapy. (c) 2016 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.progpolymsci.2016.01.002
ISSN: 0079-6700
DOI: 10.1016/j.progpolymsci.2016.01.002
Volume: 57
Begin Page: 153
End Page: 178
Appears in Collections:Articles