標題: Vitamin D-3 Reduces Tissue Damage and Oxidative Stress Caused by Exhaustive Exercise
作者: Ke, Chun-Yen
Yang, Fwu-Lin
Wu, Wen-Tien
Chung, Chen-Han
Lee, Ru-Ping
Yang, Wan-Ting
Subeq, Yi-Maun
Liao, Kuang-Wen
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Calcitriol;4-Hydroxynonenal;lipid peroxidation
公開日期: 2016
摘要: Exhaustive exercise results in inflammation and oxidative stress, which can damage tissue. Previous studies have shown that vitamin D has both anti-inflammatory and antiperoxidative activity. Therefore, we aimed to test if vitamin D could reduce the damage caused by exhaustive exercise. Rats were randomized to one of four groups: control, vitamin D, exercise, and vitamin D+exercise. Exercised rats received an intravenous injection of vitamin D (1 ng/mL) or normal saline after exhaustive exercise. Blood pressure, heart rate, and blood samples were collected for biochemical testing. Histological examination and immunohistochemical (IHC) analyses were performed on lungs and kidneys after the animals were sacrificed. In comparison to the exercise group, blood markers of skeletal muscle damage, creatine kinase and lactate dehydrogenase, were significantly (P < 0.05) lower in the vitamin D+exercise group. The exercise group also had more severe tissue injury scores in the lungs (average of 2.4 +/- 0.71) and kidneys (average of 3.3 +/- 0.6) than the vitamin D-treated exercise group did (1.08 +/- 0.57 and 1.16 +/- 0.55). IHC staining showed that vitamin D reduced the oxidative product 4-Hydroxynonenal in exercised animals from 20.6% to 13.8% in the lungs and from 29.4% to 16.7% in the kidneys. In summary, postexercise intravenous injection of vitamin D can reduce the peroxidation induced by exhaustive exercise and ameliorate tissue damage, particularly in the kidneys and lungs.
URI: http://dx.doi.org/10.7150/ijms.13746
http://hdl.handle.net/11536/133130
ISSN: 1449-1907
DOI: 10.7150/ijms.13746
期刊: INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
Volume: 13
Issue: 2
起始頁: 147
結束頁: 153
顯示於類別:期刊論文