標題: CircNet: a database of circular RNAs derived from transcriptome sequencing data
作者: Liu, Yu-Chen
Li, Jian-Rong
Sun, Chuan-Hu
Andrews, Erik
Chao, Rou-Fang
Lin, Feng-Mao
Weng, Shun-Long
Hsu, Sheng-Da
Huang, Chieh-Chen
Cheng, Chao
Liu, Chun-Chi
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
生物資訊研究中心
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Center for Bioinformatics Research
公開日期: 4-Jan-2016
摘要: Circular RNAs (circRNAs) represent a new type of regulatory noncoding RNA that only recently has been identified and cataloged. Emerging evidence indicates that circRNAs exert a new layer of post-transcriptional regulation of gene expression. In this study, we utilized transcriptome sequencing datasets to systematically identify the expression of circRNAs (including known and newly identified ones by our pipeline) in 464 RNA-seq samples, and then constructed the CircNet database (http://circnet.mbc.nctu.edu.tw/) that provides the following resources: (i) novel circRNAs, (ii) integrated miRNAtarget networks, (iii) expression profiles of circRNA isoforms, (iv) genomic annotations of circRNA isoforms (e. g. 282 948 exon positions), and (v) sequences of circRNA isoforms. The CircNet database is to our knowledge the first public database that provides tissue-specific circRNA expression profiles and circRNA-miRNA-gene regulatory networks. It not only extends themost up to date catalog of circRNAs but also provides a thorough expression analysis of both previously reported and novel circRNAs. Furthermore, it generates an integrated regulatory network that illustrates the regulation between circRNAs, miRNAs and genes.
URI: http://dx.doi.org/10.1093/nar/gkv940
http://hdl.handle.net/11536/133119
ISSN: 0305-1048
DOI: 10.1093/nar/gkv940
期刊: NUCLEIC ACIDS RESEARCH
Volume: 44
Issue: D1
起始頁: 0
結束頁: 0
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