標題: miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database
作者: Chou, Chih-Hung
Chang, Nai-Wen
Shrestha, Sirjana
Hsu, Sheng-Da
Lin, Yu-Ling
Lee, Wei-Hsiang
Yang, Chi-Dung
Hong, Hsiao-Chin
Wei, Ting-Yen
Tu, Siang-Jyun
Tsai, Tzi-Ren
Ho, Shu-Yi
Jian, Ting-Yan
Wu, Hsin-Yi
Chen, Pin-Rong
Lin, Nai-Chieh
Huang, Hsin-Tzu
Yang, Tzu-Ling
Pai, Chung-Yuan
Tai, Chun-San
Chen, Wen-Liang
Huang, Chia-Yen
Liu, Chun-Chi
Weng, Shun-Long
Liao, Kuang-Wen
Hsu, Wen-Lian
Huang, Hsien-Da
交大名義發表
生物科技學系
生物資訊及系統生物研究所
分子醫學與生物工程研究所
生物資訊研究中心
National Chiao Tung University
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Institute of Molecular Medicine and Bioengineering
Center for Bioinformatics Research
公開日期: 4-Jan-2016
摘要: MicroRNAs (miRNAs) are small non-coding RNAs of approximately 22 nucleotides, which negatively regulate the gene expression at the post-transcriptional level. This study describes an update of the miRTarBase (http://miRTarBase.mbc.nctu.edu.tw/) that provides information about experimentally validated miRNA-target interactions (MTIs). The latest update of the miRTarBase expanded it to identify systematically Argonaute-miRNA-RNA interactions from 138 crosslinking and immunoprecipitation sequencing (CLIP-seq) data sets that were generated by 21 independent studies. The database contains 4966 articles, 7439 strongly validated MTIs (using reporter assays or western blots) and 348 007 MTIs from CLIP-seq. The number of MTIs in the miRTarBase has increased around 7-fold since the 2014 miRTarBase update. The miRNA and gene expression profiles from The Cancer Genome Atlas (TCGA) are integrated to provide an effective overview of this exponential growth in the miRNA experimental data. These improvements make the miRTarBase one of the more comprehensively annotated, experimentally validated miRNA-target interactions databases and motivate additional miRNA research efforts.
URI: http://dx.doi.org/10.1093/nar/gkv1258
http://hdl.handle.net/11536/133085
ISSN: 0305-1048
DOI: 10.1093/nar/gkv1258
期刊: NUCLEIC ACIDS RESEARCH
Volume: 44
Issue: D1
起始頁: 0
結束頁: 0
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