標題: Palladium-Catalyzed Selective Aryl Ring C-H Activation of N-Acyl-2-aminobiaryls: Efficient Access to Multiaryl-Substituted Naphthalenes
作者: Annamalai, Pratheepkumar
Chen, Wu-Yin
Raju, Selvam
Hsu, Kou-Chi
Upadhyay, Nitinkumar Satyadev
Cheng, Chien-Hong
Chuang, Shih-Ching
應用化學系
Department of Applied Chemistry
關鍵字: alkynes;aromatic homologation;C-H activation;naphthalenes;palladium
公開日期: 17-Nov-2016
摘要: Palladium-catalyzed cycloaromatization of N-acyl-2-aminobiaryls, through a sequence of ortho C-H bond activation/alkyne insertion/meta C-H bond activation/alkyne insertion, was developed. An efficient synthesis of multiaryl-substituted naphthalenes, N-[2-(5,6,7,8-tetraarylnaphthalen-1-yl) aryl] acetamides, was demonstrated using molecular oxygen as the sole oxidant. Furthermore, through Buchwald\'s synthetic protocol, two compounds were converted into corresponding fluorescent carbazoles in 30-40% yield by intramolecular C-N bond formation.
URI: http://dx.doi.org/10.1002/adsc.201600488
http://hdl.handle.net/11536/133000
ISSN: 1615-4150
DOI: 10.1002/adsc.201600488
期刊: ADVANCED SYNTHESIS & CATALYSIS
Volume: 358
Issue: 22
起始頁: 3642
結束頁: 3648
Appears in Collections:Articles