標題: One pot synthesis of oxygenated tri-heterocycles as anti-microbial agents
作者: Khan, IA
Kulkarni, MV
Sun, CM
應用化學系
Department of Applied Chemistry
關鍵字: coumarins;tri-heterocycles;antibacterial activity
公開日期: 1-Nov-2005
摘要: A one pot synthesis of an array of angularly linked tri-heterocycles with coumarin, benzofuran and furan rings is described. This high yielding synthesis is achieved by the reaction of various 4-bromomethylcoumarins with furyl o-hydroxyphenyl ketones involving benzylic nucleophilic displacement and intramolecular aldolization. All the compounds have been tested in vitro for their anti-microbial activity against Micrococcus aureus, Pseudomonas chinchori, Asperigillus fumigatus and Penicillium wortmanni at 100, 50, and 25 mu g ml(-1) concentrations. Chloro groups in the benzofuran ring enhanced the activity. (c) 2005 Elsevier SAS. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ejmech.2005.05.007
http://hdl.handle.net/11536/13095
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2005.05.007
期刊: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume: 40
Issue: 11
起始頁: 1168
結束頁: 1172
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