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dc.contributor.authorYang, YLen_US
dc.contributor.authorLi, SYen_US
dc.contributor.authorCheng, HHen_US
dc.contributor.authorLo, HJen_US
dc.date.accessioned2014-12-08T15:18:04Z-
dc.date.available2014-12-08T15:18:04Z-
dc.date.issued2005-11-03en_US
dc.identifier.issn1471-2334en_US
dc.identifier.urihttp://dx.doi.org/10.1186/1471-2334-5-99en_US
dc.identifier.urihttp://hdl.handle.net/11536/13071-
dc.description.abstractBackground: Candida species have various degrees of susceptibility to common antifungal drugs. The extent of resistance to amphotericin B and fluconazole of Candida glabrata isolates causing candidemia has been reported. Active surveillance may help us to monitor the trend of susceptibility to antifungal drugs and to determine if there is an emerging co-resistance to both drugs of Candida species, specifically, of C. glabrata in Taiwan. Methods: The susceptibilities to amphotericin B and fluconazole of Candida species collected in 1999 and 2002 of the Taiwan Surveillance of Antimicrobial Resistance of Yeasts (TSARY) were determined by the microdilution method. Results: The antifungal susceptibilities of 342 and 456 isolates collected from 11 hospitals participating in both TSARY 1999 and TSARY 2002, respectively, have been determined. The resistance rate to amphotericin B has increased from 0.3% in the TSARY1999 to 2.2% in the TSARY 2002. In contrast, the resistance rate to fluconazole has decreased from 8.8% to 2.2%. Nevertheless, significantly more C. glabrata isolates were not susceptible to fluconazole in the TSARY 2002 (47.4%) than that in the TSARY 1999 (20.8%). There were 9.8% and 11% of C. glabrata isolates having susceptible-dose dependent and resistant phenotype to fluconazole in the TSARY 1999, verse 45.3% and 2.1% in the TSARY 2002. Conclusion: There was an increase of resistance rate to amphotericin B in C. glabrata. On the other hand, although the resistance rate to fluconazole has decreased, almost half of C. glabrata isolates were not susceptible to this drug. Hence, continuous monitoring the emerging of coresistance to both amphotericin B and fluconazole of Candida species, specifically, of C. glabrata, will be an important early-warning system.en_US
dc.language.isoen_USen_US
dc.titleThe trend of susceptibilities to amphotericin B and fluconazole of Candida species from 1999 to 2002 in Taiwanen_US
dc.typeArticleen_US
dc.identifier.doi10.1186/1471-2334-5-99en_US
dc.identifier.journalBMC INFECTIOUS DISEASESen_US
dc.citation.volume5en_US
dc.citation.issueen_US
dc.citation.epageen_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000233650200001-
dc.citation.woscount14-
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