Title: Womb-on-a-chip biomimetic system for improved embryo culture and development
Authors: Chang, Kuo-Wei
Chang, Pei-Yu
Huang, Hong-Yuan
Li, Chin-Jung
Tien, Chang-Hung
Yao, Da-Jeng
Fan, Shih-Kang
Hsu, Wensyang
Liu, Cheng-Hsien
Department of Mechanical Engineering
Keywords: Biomimetic microsystem;Embryo;Endometrial stromal cell;Embryonic development
Issue Date: 1-Apr-2016
Abstract: The 3D biomimetic microsystem described in this research integrates various functions of the fallopian tube to serve as an in vitro platform for fertilization and embryonic development. This device mimics the in vivo embryo-endometrial stromal cell monolayer coculture to enhance the group culture of embryos and mechanically culture the embryos in a dynamic manner to enhance their development. The microdevice presented here is compared with static culture for embryonic development rate in the presence and absence of epithelial cells. The results suggest that the dynamic biomimetic microsystem enhances the rate of embryo development, providing a culture environment that closely mimics the in vivo microenvironment. This all-in-one biomimetic microsystem has the potential to replace the present embryo culture platforms used for assisting in vitro fertilization. (C) 2015 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.snb.2015.11.004
ISSN: 0925-4005
DOI: 10.1016/j.snb.2015.11.004
Volume: 226
Begin Page: 218
End Page: 226
Appears in Collections:Articles