標題: Development of nordihydroguaiaretic acid derivatives as potential multidrug-resistant selective agents for cancer treatment
作者: Huang, Lin-Chiang Sherlock
Chuang, Hong
Kapoor, Mohit
Hsieh, Cheng-Ying
Chou, Shih-Ching
Lin, Hui-Hsien
Chen, Yi-Wei
Chang, Chia-Ching
Hwu, Jih-Ru
Liang, Yu-Chuan
Hsu, Ming-Hua
生物科技學系
Department of Biological Science and Technology
公開日期: 1-Jan-2015
摘要: In this research, we designed and synthesized a new series of nordihydroguaiaretic acid (NDGA) derivatives for multidrug resistance (MDR) research. A methylsulfonyl NDGA derivative, ((2R,3S)-2,3-dimethylbutane-1,4-diyl)bis(benzene-4,1,2-triyl) tetramethanesulfonate (5d), was found to inhibit MDR1 gene expression and suppress drug resistantMES-SA/Dx5 cells. Moreover, the combination of 5d and doxorubicin/terameprocol (M4N) showed a profound synergistic effect on inhibition of drug resistant cancer cells, suggesting that 5d is a potential adjuvant applied with doxorubicin or terameprocol in cancer treatment.
URI: http://dx.doi.org/10.1039/c5ra18827j
http://hdl.handle.net/11536/129600
ISSN: 2046-2069
DOI: 10.1039/c5ra18827j
期刊: RSC ADVANCES
Volume: 5
Issue: 130
起始頁: 107833
結束頁: 107838
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