標題: Is Zolpidem Associated with Increased Risk of Fractures in the Elderly with Sleep Disorders? A Nationwide Case Cross-Over Study in Taiwan
作者: Tang, Yih-Jing
Ho, Shinn-Ying
Chu, Fang-Ying
Chen, Hung-An
Yin, Yun-Ju
Lee, Hua-Chin
Chu, William Cheng-Chung
Yeh, Hui-Wen
Chiang, Wei-Shan
Yeh, Chia-Lun
Huang, Hui-Ling
Tzeng, Nian-Sheng
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 30-Dec-2015
摘要: Background We conducted a study using a case-crossover design to clarify the risk of acute effects of zolpidem and benzodiazepine on all-sites of fractures in the elderly. Design of study Case-crossover design. Methods and Materials Elderly enrollees (n = 6010) in Taiwan's National Health Insurance Research Database with zolpidem or benzodiazepine use were analyzed for the risk of developing fractures. Results After adjusting for medications such as antipsychotics, antidepressants, and diuretics, or comorbidities such as hypertension, osteoarthritis, osteoporosis, rheumatoid arthritis and depression, neither zolpidem nor benzodiazepine was found to be associated with increased risk in all-sites fractures. Subjects without depression were found to have an increased risk of fractures. Diazepam is the only benzodiazepine with increased risk of fractures after adjusting for medications and comorbidities. Hip and spine were particular sites for increased fracture risk, but following adjustment for comorbidities, the associations were found to be insignificant. Conclusion Neither zolpidem nor benzodiazepine was associated with increased risk of all-site fractures in this case cross-over study after adjusting for medications or comorbidities in elderly individuals with insomnia. Clinicians should balance the benefits and risks for prescribing zolpidem or benzodiazepine in the elderly accordingly.
URI: http://dx.doi.org/10.1371/journal.pone.0146030
http://hdl.handle.net/11536/129522
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0146030
期刊: PLOS ONE
Volume: 10
Issue: 12
起始頁: 0
結束頁: 0
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