標題: Evaluation of traumatic brain injury by optical technique
作者: Lin, Bor-Shyh
Wang, Che-Chuan
Chang, Ming-Hsien
Chio, Chung-Ching
光電系統研究所
影像與生醫光電研究所
Institute of Photonic System
Institute of Imaging and Biomedical Photonics
關鍵字: Deoxyhemoglobin;Infarction volume;Near-infrared spectroscopy;Oxyhemoglobin;Traumatic brain injury;Triphenyltetrazolium chloride
公開日期: 14-Oct-2015
摘要: Background: Traumatic brain injury (TBI), usually due to brain shaking or impact, affects the normal brain function and may lead to severe disability or even death. However, there is paucity of information regarding changes in the physiologic state of humans or animals after brain shaking. Methods: In this study, near-infrared spectroscopy (NIRS) was used to continuously monitor the concentration change of oxy-hemoglobin (HbO2) and deoxy-hemoglobin (HbR) to understand changes in the physiological state during and after brain shaking. Laser Doppler flowmetry was also used to monitor changes in cerebral blood flow under TBI to supplement the investigation. Triphenyltetrazolium chloride (TTC) staining was used to monitor changes of infarction volume corresponding to different impact strengths. Result: The experimental results indicated that concentration changes of HbO2 and total-hemoglobin (HbT) were significantly related to the impact strength. The infarction volume was also significantly related to the impact strength. Conclusion: Therefore, the non-invasive monitoring of concentration changes in HbO2, HbR, and HbT using NIRS may have a clinical application for the evaluation of TBI.
URI: http://dx.doi.org/10.1186/s12883-015-0465-3
http://hdl.handle.net/11536/128224
ISSN: 1471-2377
DOI: 10.1186/s12883-015-0465-3
期刊: BMC NEUROLOGY
Volume: 15
起始頁: 0
結束頁: 0
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