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dc.contributor.authorFu Ou-Yangen_US
dc.contributor.authorLin, Yu-Daen_US
dc.contributor.authorChuang, Li-Yehen_US
dc.contributor.authorChang, Hsueh-Weien_US
dc.contributor.authorYang, Cheng-Hongen_US
dc.contributor.authorHou, Ming-Fengen_US
dc.date.accessioned2019-04-03T06:35:53Z-
dc.date.available2019-04-03T06:35:53Z-
dc.date.issued2015-01-01en_US
dc.identifier.issn2314-6133en_US
dc.identifier.urihttp://dx.doi.org/10.1155/2015/281263en_US
dc.identifier.urihttp://hdl.handle.net/11536/128186-
dc.description.abstractThe ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated. Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene. Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed lowvalues of odds ratios (0.409-0.425) for breast cancer association. Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.en_US
dc.language.isoen_USen_US
dc.titleThe Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwaneseen_US
dc.typeArticleen_US
dc.identifier.doi10.1155/2015/281263en_US
dc.identifier.journalBIOMED RESEARCH INTERNATIONALen_US
dc.citation.spage0en_US
dc.citation.epage0en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000360722600001en_US
dc.citation.woscount0en_US
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