標題: The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese
作者: Fu Ou-Yang
Lin, Yu-Da
Chuang, Li-Yeh
Chang, Hsueh-Wei
Yang, Cheng-Hong
Hou, Ming-Feng
生物科技學系
Department of Biological Science and Technology
公開日期: 1-Jan-2015
摘要: The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated. Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene. Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed lowvalues of odds ratios (0.409-0.425) for breast cancer association. Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.
URI: http://dx.doi.org/10.1155/2015/281263
http://hdl.handle.net/11536/128186
ISSN: 2314-6133
DOI: 10.1155/2015/281263
期刊: BIOMED RESEARCH INTERNATIONAL
起始頁: 0
結束頁: 0
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