標題: (PS)(2): protein structure prediction server version 3.0
作者: Huang, Tsun-Tsao
Hwang, Jenn-Kang
Chen, Chu-Huang
Chu, Chih-Sheng
Lee, Chi-Wen
Chen, Chih-Chieh
生物科技學系
生物資訊及系統生物研究所
生物資訊研究中心
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Center for Bioinformatics Research
公開日期: 1-Jul-2015
摘要: Protein complexes are involved in many biological processes. Examining coupling between subunits of a complexwould be useful to understand themolecular basis of protein function. Here, our updated (PS)(2) web server predicts the three-dimensional structures of protein complexes based on comparative modeling; furthermore, this server examines the coupling between subunits of the predicted complex by combining structural and evolutionary considerations. The predicted complex structure could be indicated and visualized by Java-based 3D graphics viewers and the structural and evolutionary profiles are shown and compared chain-by-chain. For each subunit, considerations with or without the packing contribution of other subunits cause the differences in similarities between structural and evolutionary profiles, and these differences imply which form, complex or monomeric, is preferred in the biological condition for the subunit. We believe that the (PS)(2) server would be a useful tool for biologists who are interested not only in the structures of protein complexes but also in the coupling between subunits of the complexes. The (PS)(2) is freely available at http://ps2v3.life.nctu.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkv454
http://hdl.handle.net/11536/128178
ISSN: 0305-1048
DOI: 10.1093/nar/gkv454
期刊: NUCLEIC ACIDS RESEARCH
Volume: 43
Issue: W1
起始頁: 0
結束頁: 0
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