標題: Parallel synthesis and biological evolution of quinic acid derivatives as immuno-suppressing agents against T-cell receptors
作者: Huang, Chih-Yu
Chen, Li-Hsun
Huang, Hsuan-Yu
Kao, Feng-Sheng
Lee, Yun-Ta
Selvaraju, Manikandan
Sun, Chung-Ming
Chen, Hueih-Min
應用化學系
Department of Applied Chemistry
公開日期: 1-Jan-2015
摘要: A simple protocol for the synthesis of quinic acid derivatives was established and their biological evolution against T-cells is studied. Results showed that one of the derivatives, Cyn-1324, has low toxicity on T-cells and a high effect on reducing Signal 2 of T-cell immune responses. In vitro binding measurements of atomic force spectroscopy further indicated that the blocking effect of Cyn-1324 between CD28 and CD80 was about 31 + 4%. In vivo animal tests also confirmed that Cyn-1324 can reduce the allergic responses from ovalbumin-induced mice with little toxicity. Based on these observations, Cyn-1324 can be a mild immuno-suppressive candidate for future drug development.
URI: http://dx.doi.org/10.1039/c5ra06095h
http://hdl.handle.net/11536/127954
ISSN: 2046-2069
DOI: 10.1039/c5ra06095h
期刊: RSC ADVANCES
Volume: 5
Issue: 63
起始頁: 50801
結束頁: 50806
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