Title: Electrical-Sensitive Nanoparticle Composed of Chitosan and Tetraethyl Orthosilicate for Controlled Drug Release
Authors: Liu, Kun-Ho
Liu, Ting-Yu
Liu, Dean-Mo
Chen, San-Yuan
Department of Materials Science and Engineering
Keywords: Polyelectrolyte;Electric-Stimuli;Nanoparticle
Issue Date: 1-Feb-2009
Abstract: In the present study, the nanoparticles with size of 50-130 nm composed of chitosan (CS) and tetraethyl orthosilicate (TEOS), which showed electrically-control led release profile, were prepared. Myoglobin was encapsulated into the nanoparticles with an encapsulation efficiency as high as 91.5% and a maximum loading capacity of 70.2% that can be achieved. Here, TEOS was hydrolyzed and condensed to form interpenetration network with CS. Increase of TEOS content results in a shift of the release profile from swelling-controlled towards diffusion-controlled mechanism. The "slow-to-burst" and "near-zero" release of the myoglobin can be effectively controlled by applying DC electric field between "on" and "off."
URI: http://dx.doi.org/10.1166/jnn.2009.C119
ISSN: 1533-4880
DOI: 10.1166/jnn.2009.C119
Volume: 9
Issue: 2
Begin Page: 1198
End Page: 1203
Appears in Collections:Conferences Paper