標題: Is schizophrenia associated with an increased risk of chronic kidney disease? A nationwide matched-cohort study
作者: Tzeng, Nian-Sheng
Hsu, Yung-Ho
Ho, Shinn-Ying
Kuo, Yu-Ching
Lee, Hua-Chin
Yin, Yun-Ju
Chen, Hong-An
Chen, Wen-Liang
Chu, William Cheng-Chung
Huang, Hui-Ling
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 1-一月-2015
摘要: Objective: The impact of schizophrenia on vital diseases, such as chronic kidney disease (CKD), has not as yet been verified. This study aims to establish whether there is an association between schizophrenia and CKD. Design: A nationwide matched cohort study. Setting: Taiwan\'s National Health Insurance Research Database. Participants: A total of 2338 patients with schizophrenia, and 7014 controls without schizophrenia (1: 3), matched cohort for sex, age group, geography, urbanisation and monthly income, between 1 January 2003 and 31 December 2007, based on the International Classifications of Disease Ninth Edition (ICD-9), Clinical Modification codes. Primary and secondary outcome measures: After making adjustments for confounding risk factors, a Cox proportional hazards model was used to compare the risk of developing CKD during a 3-year follow-up period from the index date. Results: Of the 2338-subject case cohort, 163 (6.97%) developed a CKD, as did 365 (5.20%) of the 7014 control participants. Cox proportional hazards regression analysis revealed that patients with schizophrenia were more likely to develop CKD (HR = 1.36, 95% CI 1.13 to 1.63; p < 0.001). After adjusting for gender, age group, hypertension, diabetes mellitus, hyperlipidaemia, heart disease and nonsteroid anti-inflammatory drugs (NSAIDs) usage, the HR for patients with schizophrenia was 1.25 (95% CI 1.04 to 1.50; p < 0.05). Neither typical nor atypical antipsychotics was associated an increased risk of CKD in patients with schizophrenia. Conclusions: The findings from this population-based retrospective cohort study suggest that schizophrenia is associated with a 25% increase in the risk of developing CKD within only a 3-year follow-up period.
URI: http://dx.doi.org/10.1136/bmjopen-2014-006777
http://hdl.handle.net/11536/124861
ISSN: 2044-6055
DOI: 10.1136/bmjopen-2014-006777
期刊: BMJ OPEN
顯示於類別:期刊論文