Title: A highly selective fluorescent sensor for Hg(II) based on an NTe2 chelating motif and its application to living cell imaging
Authors: Kao, Shao-Lun
Venkatesan, Parthiban
Wu, Shu-Pao
Department of Applied Chemistry
Issue Date: 1-Jan-2015
Abstract: A fluorescent probe (NBDTe) based on an NTe2 chelating motif has been developed for the highly selective and sensitive detection of Hg2+. Significant fluorescence enhancement was observed with the chemosensor NBDTe in the presence of Hg2+. Moreover, the metal ions Ag+, Al3+, Ca2+, Cd2+, Co2+, Cu2+, Cr3+, Fe2+, Fe3+, Hg2+, Mg2+, Mn2+, Ni2+, Pb2+, and Zn2+ produced only minor changes in the fluorescence values of the system. The association constant (K-a) of Hg2+ binding to the chemosensor NBDTe was found to be 3.81 x 10(3) M (1), with a detection limit of 4.2 mu M. The maximum fluorescence enhancement caused by Hg2+ binding to the chemosensor NBDTe was observed over the pH range of 4.0-10.0. In addition, fluorescence microscopy experiments showed that the chemosensor NBDTe can be used as a fluorescent probe for detecting Hg2+ in living cells.
URI: http://dx.doi.org/10.1039/c5nj00159e
ISSN: 1144-0546
DOI: 10.1039/c5nj00159e
Volume: 39
Begin Page: 3551
End Page: 3557
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