Title: Microwave-assisted efficient conjugation of nanodiamond and paclitaxel
Authors: Hsieh, Yi-Han
Liu, Kuang-Kai
Sulake, Rohidas S.
Chao, Jui-I.
Chen, Chinpiao
Department of Biological Science and Technology
Keywords: Nanodiamond;Paclitaxel;Microwave irradiating;Deaggregation;Lung cancer
Issue Date: 15-May-2015
Abstract: Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond. (C) 2015 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bmcl.2015.03.089
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2015.03.089
Volume: 25
Issue: 10
Begin Page: 2074
End Page: 2077
Appears in Collections:Articles