標題: Molecular epidemiology of long-term colonization of Candida albicans strains from HIV-infected patients
作者: Li, SY
Yang, YL
Chen, KW
Cheng, HH
Chiou, CS
Wang, TH
Lauderdale, TL
Hung, CC
Lo, HJ
生物科技學系
Department of Biological Science and Technology
公開日期: 1-Apr-2006
摘要: Twenty-one Candida albicans isolates from three HIV-infected patients were collected over a period of 3 years and characterized for fluconazole susceptibility, infectivity and genetic relatedness. Fluconazole resistance was found in five isolates, four exhibited dose-dependent susceptibility and the remainder were fully susceptible to this agent. Pulsed-field gel clectrophoresis of SfiI restriction digests of the genomic DNA from the isolates revealed that isolates from the same swab specimen were identical despite differences in Susceptibility to fluconazole and isolates recovered over time from the three patients retained clonally related DNA fingerprints within each patient. This small-scale study confirms the persistence of oral colonization of C. albicans strains in HIV-infected patients. Clinical data also suggests that the primary infecting strain may become a persistent colonist in the oral cavity once the immune function of the patient has been restored.
URI: http://dx.doi.org/10.1017/S0950268805004905
http://hdl.handle.net/11536/12442
ISSN: 0950-2688
DOI: 10.1017/S0950268805004905
期刊: EPIDEMIOLOGY AND INFECTION
Volume: 134
Issue: 2
起始頁: 265
結束頁: 269
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