標題: Alternative RNA Structure-Coupled Gene Regulations in Tumorigenesis
作者: Chen, Feng-Chi
生物科技學系
Department of Biological Science and Technology
關鍵字: gene regulation;alternative splicing;alternative promoter usage;alternative cleavage and polyadenylation;untranslated region;nonsense-mediated decay;upstream open reading frame;internal ribosome entry site;microRNA;tumorigenesis
公開日期: 1-一月-2015
摘要: Alternative RNA structures (ARSs), or alternative transcript isoforms, are critical for regulating cellular phenotypes in humans. In addition to generating functionally diverse protein isoforms from a single gene, ARS can alter the sequence contents of 5\'/3\' untranslated regions (UTRs) and intronic regions, thus also affecting the regulatory effects of these regions. ARS may introduce premature stop codon(s) into a transcript, and render the transcript susceptible to nonsense-mediated decay, which in turn can influence the overall gene expression level. Meanwhile, ARS can regulate the presence/absence of upstream open reading frames and microRNA targeting sites in 5\'UTRs and 3\'UTRs, respectively, thus affecting translational efficiencies and protein expression levels. Furthermore, since ARS may alter exon-intron structures, it can influence the biogenesis of intronic microRNAs and indirectly affect the expression of the target genes of these microRNAs. The connections between ARS and multiple regulatory mechanisms underline the importance of ARS in determining cell fate. Accumulating evidence indicates that ARS-coupled regulations play important roles in tumorigenesis. Here I will review our current knowledge in this field, and discuss potential future directions.
URI: http://dx.doi.org/10.3390/ijms16010452
http://hdl.handle.net/11536/124413
ISSN: 1422-0067
DOI: 10.3390/ijms16010452
期刊: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume: 16
起始頁: 452
結束頁: 475
顯示於類別:期刊論文