標題: Tyrosine Sulfation as a Protein Post-Translational Modification
作者: Yang, Yuh-Shyong
Wang, Chen-Chu
Chen, Bo-Han
Hou, You-Hua
Hung, Kuo-Sheng
Mao, Yi-Chih
生物科技學系
Department of Biological Science and Technology
公開日期: 1-二月-2015
摘要: Integration of inorganic sulfate into biological molecules plays an important role in biological systems and is directly involved in the instigation of diseases. Protein tyrosine sulfation (PTS) is a common post-translational modification that was first reported in the literature fifty years ago. However, the significance of PTS under physiological conditions and its link to diseases have just begun to be appreciated in recent years. PTS is catalyzed by tyrosylprotein sulfotransferase (TPST) through transfer of an activated sulfate from 3\'-phosphoadenosine-5\'-phosphosulfate to tyrosine in a variety of proteins and peptides. Currently, only a small fraction of sulfated proteins is known and the understanding of the biological sulfation mechanisms is still in progress. In this review, we give an introductory and selective brief review of PTS and then summarize the basic biochemical information including the activity and the preparation of TPST, methods for the determination of PTS, and kinetics and reaction mechanism of TPST. This information is fundamental for the further exploration of the function of PTS that induces protein-protein interactions and the subsequent biochemical and physiological reactions.
URI: http://dx.doi.org/10.3390/molecules20022138
http://hdl.handle.net/11536/124339
ISSN: 1420-3049
DOI: 10.3390/molecules20022138
期刊: MOLECULES
Volume: 20
起始頁: 2138
結束頁: 2164
顯示於類別:期刊論文