標題: Optimal detection angle in sub-diffraction resolution photothermal microscopy: application for high sensitivity imaging of biological tissues
作者: Miyazaki, Jun
Tsurui, Hiromichi
Kawasumi, Koshi
Kobayashi, Takayoshi
電子物理學系
Department of Electrophysics
公開日期: 11-八月-2014
摘要: We evaluated the optimal detection angle for maximizing the signal to noise ratio (SNR) in sub-diffraction resolution photothermal microscopy. The angular dependent photothermal signal was calculated based on scattering theory using the temporally modulated Yukawa potential, and its detection angle and modulation frequency dependencies were analyzed. We verified the theoretical findings by imaging gold nanoparticles using laser diode based photothermal microscopy with balanced detection scheme. High-sensitivity (SNR similar to 40) photothermal biological imaging of a mouse brain was also demonstrated.
URI: http://dx.doi.org/10.1364/OE.22.018833
http://hdl.handle.net/11536/124169
ISSN: 1094-4087
DOI: 10.1364/OE.22.018833
期刊: OPTICS EXPRESS
Volume: 22
Issue: 16
顯示於類別:期刊論文