標題: 5-Demethyltangeretin is more potent than tangeretin in inhibiting dimethylbenz(a)anthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA)-induced skin tumorigenesis
作者: Ma, Nianhan
Lai, Ching-Shu
Chung, Chih-Han
Yang, Jinn-Moon
Hsu, Kai-Cheng
Chen, Chin-Yu
Chung, Tao-Sheng
Li, Shiming
Ho, Chi-Tang
Pan, Min-Hsiung
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
關鍵字: 5-Demethyltangeretin;Tangeretin;DMBA;TPA;Inflammation
公開日期: 1-十一月-2014
摘要: 5-Demethyltangeretin (5-DTAN), an autohydrolysis product of tangeretin (TAN) found in citrus peel, exhibited more potent anti-proliferative activity in human cancer cells than TAN itself. In this study, we investigated the anti-tumor promoting effect and underlying molecular mechanism of 5-DTAN on 7,12-dimethyl-benz(a)anthracene (DMBA)-induced and 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis. Application of 5-DTAN prior to each TPA-treatment was more effective than that of TAN on reducing the number, incidence and size of papillomas in DMBA-initiated mouse skin. Moreover, 5-DTAN suppressed cyclooxygenase-2 (COX-2) protein expression more strongly than TAN through interfering with phosphatidylinositiol 3-kinase (PI3K)/Akt signaling and further activation of transcription factor NF-kappa B. Taken together, these results revealed for the first time the in vivo chemopreventive efficacy of 5-DTAN on inhibition of skin carcinogenesis through promoting apoptosis and molecular interactions with residues of PI3K, COX-2, and AKT that may potentially serve as a novel functional agent capable of preventing inflammation-associated tumorigenesis. (C) 2014 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jff.2014.08.009
http://hdl.handle.net/11536/124127
ISSN: 1756-4646
DOI: 10.1016/j.jff.2014.08.009
期刊: JOURNAL OF FUNCTIONAL FOODS
Volume: 11
起始頁: 528
結束頁: 537
顯示於類別:期刊論文


文件中的檔案:

  1. 000346885500053.pdf