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dc.contributor.authorHuang, Ching-Huien_US
dc.contributor.authorChang, Chia-Chuen_US
dc.contributor.authorKuo, Chen-Lingen_US
dc.contributor.authorHuang, Ching-Shanen_US
dc.contributor.authorLin, Chih-Shengen_US
dc.contributor.authorLiu, Chin-Sanen_US
dc.date.accessioned2019-04-03T06:40:26Z-
dc.date.available2019-04-03T06:40:26Z-
dc.date.issued2015-01-01en_US
dc.identifier.issn1449-2288en_US
dc.identifier.urihttp://dx.doi.org/10.7150/ijbs.10271en_US
dc.identifier.urihttp://hdl.handle.net/11536/124052-
dc.description.abstractBackground: Cyclophilin A (CyPA) concentration increases in acute coronary syndrome. In an animal model of acute myocardial infarction, administration of angiotensin-converting-enzyme inhibitor was associated with lower left ventricular (LV) CyPA concentration and improved LV performance. This study investigated the relationships between changes in plasma CyPA concentrations and LV remodeling in patients with ST-elevation myocardial infarction (STEMI). Methods and Results: We enrolled 55 patients who underwent percutaneous coronary intervention for acute STEMI. Plasma CyPA, matrix metalloproteinase (MMP), interleukin-6 and high-sensitivity C-reactive protein concentrations were measured at baseline and at one-month follow-up. Echocardiography was performed at baseline and at one-,three-, and six-month follow-up. Patients with a decrease in baseline CyPA concentration at one-month follow-up (n = 28) had a significant increase in LV ejection fraction (LVEF) (from 60.2 +/- 11.5% to 64.6 +/- 9.9%, p < 0. 001) and preserved LV synchrony at six months. Patients without a decrease in CyPA concentration at one month (n = 27) did not show improvement in LVEF and had a significantly increased systolic dyssynchrony index (SDI) (from 1.170 +/- 0.510% to 1.637 +/- 1.299%, p = 0.042) at six months. Multiple linear regression analysis showed a significant association between one-month CyPA concentration and six-month LVEF. The one-month MMP-2 concentration was positively correlated with one-month CyPA concentration and LV SDI. Conclusions: Decreased CyPA concentration at one-month follow-up after STEMI was associated with better LVEF and SDI at six months. Changes in CyPA, therefore, may be a prognosticator of patient outcome.en_US
dc.language.isoen_USen_US
dc.subjectAcute myocardial infarctionen_US
dc.subjectCyclophilin Aen_US
dc.subjectLeft ventricular ejection fractionen_US
dc.subjectLeft ventricular dyssynchronyen_US
dc.subjectMatrix metalloproteinaseen_US
dc.titleDecrease in Plasma Cyclophilin A Concentration at 1 Month after Myocardial Infarction Predicts Better Left Ventricular Performance and Synchronicity at 6 Months: A Pilot Study in Patients with ST Elevation Myocardial Infarctionen_US
dc.typeArticleen_US
dc.identifier.doi10.7150/ijbs.10271en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESen_US
dc.citation.volume11en_US
dc.citation.issue1en_US
dc.citation.spage38en_US
dc.citation.epage47en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000346430600005en_US
dc.citation.woscount7en_US
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