標題: Testing of Flow-Based Microfluidic Biochips: Fault Modeling, Test Generation, and Experimental Demonstration
作者: Hu, Kai
Yu, Feiqiao
Ho, Tsung-Yi
Chakrabarty, Krishnendu
資訊工程學系
Department of Computer Science
關鍵字: Automatic test pattern generation (ATPG);defects;fault modeling;lab-on-chip;microfluidics;testing
公開日期: 1-十月-2014
摘要: Recent advances in flow-based microfluidics have led to the emergence of biochemistry-on-a-chip as a new paradigm in clinical diagnostics and biomolecular recognition. However, a potential roadblock in the deployment of microfluidic biochips is the lack of test techniques to screen defective devices before they are used for biochemical analysis. Defective chips lead to repetition of experiments, which is undesirable due to high reagent cost and limited availability of samples. Prior work on fault detection in biochips has been limited to digital ("droplet") microfluidics and other electrode-based technology platforms. The paper proposes the first approach for automated testing of flow-based microfluidic biochips that are designed using membrane-based valves for flow control. The proposed test technique is based on a behavioral abstraction of physical defects in microchannels and valves. The flow paths and flow control in the microfluidic device are modeled as a logic circuit composed of Boolean gates, which allows test generation to be carried out using standard automatic test pattern generation tools. The tests derived using the logic circuit model are then mapped to fluidic operations involving pumps and pressure sensors in the biochip. Feedback from pressure sensors can be compared to expected responses based on the logic circuit model, whereby the types and positions of defects are identified. We show how a fabricated biochip can be tested using the proposed method, and demonstrate experimental results for two additional fabricated chips.
URI: http://dx.doi.org/10.1109/TCAD.2014.2336215
http://hdl.handle.net/11536/123974
ISSN: 0278-0070
DOI: 10.1109/TCAD.2014.2336215
期刊: IEEE TRANSACTIONS ON COMPUTER-AIDED DESIGN OF INTEGRATED CIRCUITS AND SYSTEMS
Volume: 33
Issue: 10
起始頁: 1463
結束頁: 1475
顯示於類別:期刊論文


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  1. 000344529700003.pdf