標題: The Combination Effects of LiCl and the Active Leflunomide Metabolite, A771726, on Viral-Induced Interleukin 6 Production and EV-A71 Replication
作者: Hung, Hui-Chen
Shih, Shin-Ru
Chang, Teng-Yuan
Fang, Ming-Yu
Hsu, John T. -A.
生物科技學系
Department of Biological Science and Technology
公開日期: 20-十一月-2014
摘要: Enterovirus 71 (EV-A71) is a neurotropic virus that can cause severe complications involving the central nervous system. No effective antiviral therapeutics are available for treating EV-A71 infection and drug discovery efforts are rarely focused to target this disease. Thus, the main goal of this study was to discover existing drugs with novel indications that may effectively inhibit EV-A71 replication and the inflammatory cytokines elevation. In this study, we showed that LiCl, a GSK3 beta inhibitor, effectively suppressed EV-A71 replication, apoptosis and inflammatory cytokines production (Interleukin 6, Interleukin-1 beta) in infected cells. Furthermore, LiCl and an immunomodular agent were shown to strongly synergize with each other in suppressing EV-A71 replication. The results highlighted potential new treatment regimens in suppressing sequelae caused by EV-A71 replication.
URI: http://dx.doi.org/10.1371/journal.pone.0111331
http://hdl.handle.net/11536/123896
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0111331
期刊: PLOS ONE
Issue: 11
顯示於類別:期刊論文


文件中的檔案:

  1. 000345253000007.pdf