標題: Detection of discriminative sequence motifs in proteins obtained from prokaryotes grown at various temperatures
作者: Wu, LC
Horng, JT
Huang, SL
Huang, HD
Liu, BJ
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: protein thermostability;protein motif
公開日期: 30-Apr-2006
摘要: Recent investigations on the stability of proteins have demonstrated various structural factors, but few have considered sequence factors such as protein motifs. These motifs represent highly conserved regions and describe critical regions that may only exist on proteins that remain functional at high temperatures. This investigation presents a method for identifying and comparing corresponding mesophilic and thermophilic sequence motifs between protein families. Discriminative motifs that are conserved only in the mesophilic or thermophilic subfamily are identified. Analysis of the results shows that, although the subfamilies of most protein families share similar motifs, some discriminative motifs are present in particular thermophilic/mesophilic subfamilies. The thermophilic discriminative motifs are conserved only in thermophilic organisms, revealing that physiochemical principles support thermostability. (c) 2006 Wiley Periodicals, Inc.
URI: http://dx.doi.org/10.1002/jcc.20391
http://hdl.handle.net/11536/12354
ISSN: 0192-8651
DOI: 10.1002/jcc.20391
期刊: JOURNAL OF COMPUTATIONAL CHEMISTRY
Volume: 27
Issue: 6
起始頁: 798
結束頁: 808
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