標題: Constructing quantitative models from qualitative mutant phenotypes: preferences in selecting sensory organ precursors
作者: Hsu, CP
Lee, PH
Chang, CW
Lee, CT
應用化學系分子科學碩博班
Institute of Molecular science
公開日期: 1-Jun-2006
摘要: Motivation: To study biology from the systems level, mathematical models that describe the time-evolution of the system offer useful insights. Quantitative information is required for constructing such models, but such information is rarely provided. Results: We propose a scheme-based on random searches over a parameter space, according to criteria set by qualitative experimental observations-for inferring quantitative parameters from qualitative experimental results. We used five mutant constraints to construct genetic network models for sensory organ precursor formation in Drosophila development. Most of the models were capable of generating expression patterns for the gene Enhancer of split that were compatible with experimental observations for wild type and two Notch mutants. We further examined factors differentiating the neural fate among cells in a proneural cluster, and found two opposite driving forces that bias the choice between middle cells and the peripheral cells. Therefore, it is possible to build numerical models from mutant screening and to study mechanisms behind the complicated network.
URI: http://dx.doi.org/10.1093/bioinformatics/btl082
http://hdl.handle.net/11536/12205
ISSN: 1367-4803
DOI: 10.1093/bioinformatics/btl082
期刊: BIOINFORMATICS
Volume: 22
Issue: 11
起始頁: 1375
結束頁: 1382
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