標題: Biological data warehousing system for identifying transcriptional regulatory sites from gene expressions of microarray data
作者: Tsou, Ann-Ping
Sun, Yi-Ming
Liu, Chia-Lin
Huang, Hsien-Da
Horng, Jorng-Tzong
Tsai, Meng-Feng
Liu, Baw-Juine
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: databases;data warehouse;gene expression;gene regulation;microarray;regulatory sites;synexpression group;transcription factor
公開日期: 1-七月-2006
摘要: Identification of transcriptional regulatory sites plays an important role in the investigation of gene regulation. For this propose, we designed and implemented a data warehouse to integrate multiple heterogeneous biological data sources with data types such as text-file, XML, image, MySQL database model, and Oracle database model. The utility of the biological data warehouse in predicting transcriptional regulatory sites of coregulated genes was explored using a synexpression group derived from a microarray study. Both of the binding sites of known transcription factors and predicted over-represented (OR) oligonucleotides were demonstrated for the gene group. The potential biological roles of both known nucleotides and one OR nucleotide were demonstrated using bioassays. Therefore, the results from the wet-lab experiments reinforce the power and utility of the data warehouse as an approach to the genome-wide search for important transcription regulatory elements that are the key to many complex biological systems.
URI: http://dx.doi.org/10.1109/TITB.2005.862466
http://hdl.handle.net/11536/12095
ISSN: 1089-7771
DOI: 10.1109/TITB.2005.862466
期刊: IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE
Volume: 10
Issue: 3
起始頁: 550
結束頁: 558
顯示於類別:期刊論文


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  1. 000239033000017.pdf